Applications include topical, ear, or eye drop, or as a spray for other sensitive tissues. It does not sting, burn, or otherwise hurt even the most sensitive areas.

It can be used on cold sores, warts, open sores, or a spray for acne, eczema, and other skin irritations like Molluscum contagiosum, even atomized. The number of disease organisms presently identified that colloid of silver is fatal to is now over 650.